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If the body is considered as the whole system clearing the drug, Cl can also be determined by the animals cardiac output and the extraction ratio (E), where E is a numerical value between 0 and 1 that is the percentage of the drug that is cleared by a single pass through the clearing organ: For a drug with an extraction ratio of 1 (100% removal by the liver and kidney on the first pass), then the expected value of Cl is about 50% of the cardiac output, because blood flow to the liver and the kidneys represents about half of the cardiac output

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D., & Yajnik, C