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Through ADP-ribosylation of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase by polyADP-ribose polymerase, ROS and advanced glycation end product (AGEs) production will rise (Figure 8) (Eelen et al., Figure 8 Furthermore, it has been hypothesized that glycogen stores in ECs are used as a backup source of energy when ECs migrate to regions with low glucose concentration (Bierhansl et al., 2016)