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Additionally, the inhibition of LAMP2 A reduced cytokine release and heightened sensitivity to temozolomide, alongside in vivo studies confirming reduced tumorigenicity and increased lifespan in murine models [282]

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Additionally, ligand-trap agents such as luspatercept (TGF-/activin inhibition, facilitating late-stage erythroid differentiation) (Santini and Consagra, 2025), BRAF inhibitors that treat anemia through activation of MAPK signaling (Wu et al., 2024), and low-cost host-defense peptides with anti-inflammatory properties (e.g., IDR-1018) ( Figure 1 Statements Author contributions F-FL: Investigation, Writing original draft

J Phys Chem B 120(33):8416-23, 2016

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The raw dataset was uploaded to www.ebi.ac.uk/metabolights/MTBLS5401