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Demyelination in Multiple Sclerosis: Reprogramming Energy Metabolism and Potential PPARgamma Agonist Treatment Approaches

All three symptom domains could be effectively treated by mGlu5 positive allosteric modulators, which are devoid of toxicity and seizure liability according to preclinical data

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10.3389/fphys.2024.1499308 5 BoussugesA.BourenneJ.EloufirF.FromonotJ.MottolaG.RissoJ

Autophagy disruption influences CD by increasing Argonaute 2 (AGO2) levels to regulate differential miRNA expression [50]

One disadvantage of the CDI method is that it tends to produce ligands with a lower activity than alternative techniques (e.g., reductive amination) (Figure 14)