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In line with the UKB cohort data (ESM Table 9), vitamin B 12 deficiency was more prevalent in the AA genotype group treated with metformin vs GG (OR 2.17 [95% CI 1.80, 2.60]

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Some researchers keep a 5mg vial specifically for the first two weeks at 1mg (using just 20 units per dose), then switch to larger vials for the remainder of the protocol

It has shown remarkable healing potential, especially for joint pain, inflammation, and musculoskeletal injuries

Peer review Peer review information Nature Medicine thanks Christiana Kartsonaki, Peter Rossing, Naveed Sattar and Vikas Sridhar for their contribution to the peer review of this work

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