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The solvent-accessible surface area (SAS) buried at the interface between the subunits in the hexameric structure of Hpy GS apo and Hpy GS sub were calculated to 3,698 2 and 3,672 2 (~18% of the monomer surface area), respectively (ProteinProtein Interaction Server PDBePISA at The hexameric interface of the dodecamer was composed of C-terminal helices 13 and 14 (residues 461481), which extended to a hydrophobic hole of the opposite hexameric ring

Johnston JN, Allen J, Shkolnikov I, Sanchez-Lafuente CL, Reive BS, Scheil K, et al

In summary, disruptions in FA metabolism mediated by astrocyte mitochondria dysfunction may contribute to the pathogenesis and progression of PD, highlighting potential targets for therapeutic interventions

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& Greten, T