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Existing in this type of an environment long term can lead to many unfavorable physiologic changes

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Autophagy is a highly dynamic, multistep process involving the degradation of cytoplasmic cargo through the lysosomal machinery 51 and serves as a protective response mechanism under oxidative stress 52

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Enzyme defects in the pentose-phosphate shunt, like -glutamyl cysteine synthetase, GSH synthetase, and possibly glutathione reductase, may mimic G6PD deficiency

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