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PMID: 2706459

Sage et al

References available upon request

However, Cagrilintide failed to induce significant cFos activation in RAMP1/3 KO mice, whereas sCT retained its ability to do so, likely via residual AMY2R signaling

Safety and Tolerability: Where They Diverge Both compounds share the tolerability profile typical of appetite-suppressing metabolic peptides, but retatrutide carries additional signals that trace directly to its glucagon arm