chac1 er stress glutathione degradation Functions of glutathione-degrading enzymes in tumors. The functions of CHAC2 is essential for self-renewal

CHAC2 is essential for self renewal and glutathione maintenance in human embryonic stem cells ScienceDirect Frontiers The strategic breakdown: CHAC enzymes as regulators of glutathione homeostasis and disease implications CHAC1 degradation of glutathione enhances cystine starvation induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2 eIF2 ATF4 pathway Oncotarget Long noncoding RNA GDIL acts as a scaffold for CHAC1 and XRN2 to promote platinum resistance of colorectal cancer through inhibition of glutathione degradation Cell Death & Disease Crosstalk between Endoplasmic Reticulum Stress and Oxidative Stress in Heat Exposure Induced Apoptosis Is Dependent on the ATF4CHOPCHAC1 Signal Pathway in IPEC J2 Cells Journal of Agricultural and Food Chemistry Glutathione specific gammaglutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis Science Translational Medicine

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