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There were 13 nodes and 24 interactions in cluster 1, focusing on biological regulation, including growth factor stimulus, cellular response to stress, glucose homeostasis, and the PI3K-Akt-mTOR signaling pathway ( Figure 5B )

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64 It is reported that bacteria can metabolize the chemotherapeutic drug gemcitabine (2,2-difluorodeoxycytidine) into its inactive form (2,2-difluorodeoxyuridine), which depends on the bacterial enzyme cytidine deaminase