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Studies have shown that HIF-1 significantly increases the life span of adult Caenorhabditis elegans (Cypser and Johnson, 2002

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Measuring rapid incorporation of 14 C from glucose into amino acids in rat brain, which also is an indication of glutamineglutamate (GABA) cycle function, at many different developmental stages, Gaitonde and Richter ( 13 C-NMR determinations have similarly identified the time period during which the glutamineglutamate (GABA) cycle develops in the rat to between postnatal days 10 and 30