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Description

ATF4-C/EBP homologous protein (CHOP) is an important pathway to regulate pathological phenomena such as ER stress, ROS production, lipid peroxidation, and iron metabolism, and inhibition of this pathway prevents the progression of ferroptosis-related diseases such as acute lung injury (45)

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Epub 2007 Dec 12

G.JangI

Relevant animal studies also indicate that the infiltration and accumulation of CP-induced inflammatory cytokines within the testis serve as a key upstream mechanism leading to oligozoospermia and male fertility decline (55)

These iodine deficiency diets are usually applied in rodent models in an attempt to model human conditions of impaired production of thyroid hormones with subsequent enlargement of the thyroid gland