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HIF-1 induces the expression of EMP-related genes and enzymes to provide ample energy, mediated in CRC by HIF-1-regulated Glut1 and Glut4

For instance, combining GPX4 inhibitors with chemotherapeutic agents or radiotherapy can enhance ROS accumulation and overwhelm cellular antioxidant defences ( Figure 4 ) (105107)

PDA regulates the inflammation by assisting the body to repair the injury in a faster pace which will lead to overall reduction of inflammation

Hypoxia-induced HIF-1 directly promotes the cancer stem cell phenotype in liver cancer

Isoliquiritigenin inhibits NLRP3 inflammasome activation with CAPS mutations by suppressing caspase-1 activation and mutated NLRP3 aggregation

Triggered by ghrelin receptor activation Can lead to unintended fat gain if unmanaged Typically subsides slightly over time MK-677 significantly increased appetite due to its ghrelin-mimetic properties, making it a double-edged sword for body composition. Patel et al., The Journal of Clinical Endocrinology & Metabolism 2