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In cell experiments, zinc oxide nanoparticles significantly elevated the PINK1, Parkin, and LC3 expression levels, promoted autophagosome formation, resulting in cell cycle arrest, and inhibited tumor cell proliferation in diffuse large B-cell lymphoma, potentially explaining their anti-tumor effect

however, there are scenarios where inhibiting SIRT3 might be beneficial 181

2023;13:17 Cheng N, Rho JM, Masino SA

FDA cannot properly cite EPAs lack of action to revise the RfC and address the new literature as evidence of the lack of new and significant studies

Regulatory and commercial factors rather than safety concerns explain this limitation

The authors identified 263 upregulated and 336 downregulated differential lncRNAs between wild-type and ATG7-deficient LECs treated with H2O2, among which 24 lncRNAs showed potential interactions with 10 cataract-related miRNAs (132)