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Bidlack, PhD Estheany Romn Pagn, Universidad Ana G

In contrast, disruption of the control locus AAVS1 did not affect SP3N efficacy (Fig

Metabolomic profiles were correlated with treatment response, defined as 50% reduction from baseline HRSD 17 scores

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Current challenges in NADs development Unlike traditional small molecules and antibody drugs that exert their pharmacological effects on proteins, most NADs directly regulate gene expression, offering a broader range of targets

Although the MISEV guidelines have improved transparency and rigor in EV reporting, they primarily address minimal reporting standards and do not yet resolve critical issues related to inter- and intra-batch heterogeneity, potency assessment, or clinical-grade validation (MISEV guidelines