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The contents of Fe 2+ , Fe 3+ and total iron in the cartilage with OA injury are significantly higher than those in the cartilage without OA injury, suggesting iron deposition occurs in the cartilage during OA progression

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) is one of the most important vegetables in the world, and more than 3.8 million hm 2 of pepper are grown worldwide [16], and peppers tend to accumulate heavy metals during growth, causing toxicity [17]

When administered late upon infection, higher doses and longer treatment periods may be required due to the presence of overactive T-lymphocyte responses and uncontrolled secretion of proinflammatory cytokines, which might result in irreparable damage (42)

One way to overcome drug resistanceadministration of multiple drugs called polypharmacy has its own problems and concerns