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Neurobiology of Aging 32 (5): 763777

s., 1 H), 8.23 (d, J = 7.3 Hz, 1 H), 6.20 (dd, J = 10.1, 17.1 Hz, 1 H), 6.10 (dd, J = 2.2, 17.0 Hz, 1 H), 5.60 (dd, J = 2.4, 10.0 Hz, 1 H), 3.90 (dddd, J = 3.6, 7.2, 7.4, 11.0 Hz, 1 H), 3.26 (app d, J = 13.0 Hz, 2 H), 3.00 (app dd, J = 10.8, 22.8 Hz, 2 H), 1.92 (app dd, J = 3.1, 13.8 Hz, 2 H), 1.56 (ddd, J = 3.8, 11.8, 24.4 Hz, 2 H)

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Unfortunately, most drugs cannot pass the BBB through physiological pathways due to the extreme selectivity of the barrier

doi: 10.1172/JCI139333 81 LvMChenMZhangRZhangWWangCZhangYet al

These findings not only reveal distinct mechanisms of GSH in inhibiting cuproptosis and ferroptosis, but also suggest a potential combination strategy to suppress PDAC tumor growth