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Because of the limited research into this treatment option, it is considered a more alternative, but perfectly safe, way to manage the symptoms of fluid retention

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doi: 10.1038/ni.3577 13 OestreichKJReadKAGilbertsonSEHoughKPMcDonaldPWKrishnamoorthyVet al

It can take up to 5 years before a deficiency manifests itself clinically, and NPs should be aware and alert to the possibility of B12 deficiency in their patients on prolonged metformin

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