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Coptis japonica contains berberine, a potent natural antibacterial and anti-inflammatory compound

doi: 10.1007/S11696-024-03606-Z 88 GarcaA

Nrf2 depletion in macrophages leads to increased foam cell formation, increases the M1 inflammatory phenotype with enhanced expression of pro-inflammatory monocyte chemoattractant protein-1 and interleukin-6, and aggravates atherosclerosis (244, 245)

MOA During the bodys normal functioning an excess of oxygen containing molecules are produced, these molecules are typically very reactive with other molecules they come in contact with

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GSH, Reduced glutathione