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In PD, aggregated syn, particularly in its protofibrillar form, impairs proteasome activity, reducing its efficiency in processing both ubiquitinated and nonubiquitinated substrates [166, 167, 168]

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Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin

Clinical Pharmacokinetics, 46 (4), 281-290