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EBI mechanisms, including endothelial dysfunction, bloodbrain barrier disruption, cerebral edema, neuro-inflammation, cortical spreading depolarizations, and oxidative damage, trigger cell death and apoptosis, setting the stage for DCI development in later clinical phases

doi:10.2147/JMDH.S306350 41 Sun Y, Zhu S, Li S, Liu H

There continues to be clear evidence that people under 18 are particularly vulnerable to alcohol-related harms, and the one guideline for all adolescents gives a clear message that is in line with the current evidence

PloS ONE 4:e4345

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6 , 8 11 This plant contains small, black seeds, which have been used medicinally for millennia ( Figure 1)