If NADH is not reoxidized by methemoglobin, however, pyruvate is reduced in the lactate dehydrogenase (LDH) step, forming lactate as the final end product of glucose metabolism
doi: 10.1016/j.bbi.2019.04.037
"The pathobiology of diabetic complications: A unifying mechanism"
Likely, this could be the extended NO-system involvement (with the gastric lesions, despite inconsistencies, L-arginine has a beneficial effect, while L-NAME has an ulcerogenic effect (8, 36)), they were far less investigated in duodenal lesions (16, 17)
Further, inflammasome, in particular NLR family pyrin domain containing 3 (NLRP3) inflammasome is thought to be involved in fibroblasts [147, 148], endothelial cells, and macrophages activation in SSc [149]
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