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doi: 10.1016/j.jep.2013.12.050

This results in the protein being broken down by the cell into small, toxic fragments and these protein fragments aggregate and accumulate in neurons causing the disease

Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ

NICE recommends that overweight or obese patients aim for gradual, sustained weight loss of 510% of body weight, which has been shown to reduce liver fat and improve liver enzyme levels

Phase 2: Transition to Maintenance (Months 6-9) Once your weight has plateaued (typically around week 40-48 if you started escalation on schedule), it is time to find your maintenance dose

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