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I.ShahaniN.et al (2008)

it is also greater in patients with a history of alcohol or drug abuse

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Cancer Res 57: 14681474

Thus, while IN chelation is promising for directly targeting the brain and CNS, it still requires careful consideration of formulation strategies (e.g., nanoparticle targeting or controlled-release systems) to improve site specificity, especially for drugs with a narrow therapeutic window

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