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doi: 10.1016/j.parkreldis.2021.01.004 109 KoshimoriY.SeguraB.ChristopherL.LobaughN.Duff-CanningS.MizrahiR.et al

10.1074/jbc.M203009200 J

As the folate promotes the oligodendrocyte survival and myelination through DHFR-AMPK axis [51], therefore, folate deficiency, by impairing this DHFR-AMPK axis, can promote MS development or progression by negatively affecting oligodendrocyte survival and myelin production

Recovery of neurologic dysfunction with early intervention of vitamin B12 While red blood cells complete their regeneration cycle every 90 days, fully resolving a vitamin B12 deficiency involves more than just blood cell renewal