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Statements Author contributions VY: Conceptualization, Supervision, Writing original draft, Writing review & editing

Mar Drugs

FIGURE 6 12 Concluding remarks and future research In summary, metabolic dysfunction in T2DM affects insulin receptor signaling, inhibiting the PI3K-Akt cascade and enhancing GSK3 hyperactivity, NAD + depletion, and Sirt1/Sirt3 inactivation

The central question unifying these models in the pursuit of improved PD drug therapies is the extent to which they mirror the human condition and how reliably they forecast the successful translation of drugs into clinical settings

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The University of Manitoba's online repository for scholarly works Bov J et al (2005) Toxin-induced models of Parkinsons disease