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10.2174/0929867322666150416095114 113 LangeA

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The MAE was recalculated at each step to assess how removing additional proteins affected predictive accuracy

When all DSBs are repaired, the diplotene stage starts: the synaptonemal complex is dismantled and chimeric homologous chromosomes are only joined by chiasmata , at the crossover sites, ready to be separated by the mitotic spindle during the end of meiosis I

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It has been reported that TAM forms 4-hydroxylated metabolite, which then become quinone methides 42 and form DNA adducts in vivo 43