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Iron chelators (like deferoxamine), ROS scavengers (like N-acetylcysteine) and the canonical ferroptosis inhibitor ferrostatin-1 all attenuate this cascade, underscoring the central role of microglia-driven iron dysregulation in SCI pathology ( Ferroptotic microglia themselves amplify inflammation

Hutchison WM, Aitken PP, Wells BW (1980)

The data strongly imply that MAEE holds promise as a therapeutic agent in mitigating oxidative stress-induced damage in catfish, potentially offering a natural and effective solution to enhance cellular resilience against oxidative challenges