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Although gut bacteria have been extensively studied, intestinal fungi remain relatively under-explored, despite accounting for about 0.1% of the gut microbiota 7

After being consumed by endogenous cells and reversing their pathogenic changes, natural or synthetic EXOs interacting with them may offer therapeutic benefits (Si et al., 2023)

Shih AY, Li P, Murphy TH (2005) A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo

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However, the conversion of folic acid to active forms of folate is relatively slow in human cells ( Inter-individual variability in homocysteine, due to genetically determined metabolic heterogeneity, will likely become a fruitful area of research