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*Crystal of an inactive but processed T380A mutant using a bicistronic construct expressing large and small subunit separately

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In the reaction between formaldehyde and thiols, nucleophilic addition of the sulfur atom to the aldehyde forms a hemithioacetal ( S -hydroxymethyl adduct), which may cyclize rapidly and irreversibly with a neighboring amine to generate a thiazolidine adduct ( Figure 1B

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