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10.3389/fendo.2016.00030 96 ChoiI

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Thus, larazotide acetate appears as a therapeutic option for diseases related to increased intestinal permeability [86]

R-Lipoic acid impairs PDK binding and phosphorylation efficiency toward PDHC [185], whereas its analog CPI-613 disrupts mitochondrial metabolism by targeting PDHC and -ketoglutarate dehydrogenase/2-oxoglutarate dehydrogenase (OGDH), achieving tumor-selective cytotoxicity [186, 187]