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while some studies identified increased conjugation, others found that CeO 2 can suppress antimicrobial resistance genes transfer by reducing ROS and downregulating horizontal gene transferring genes (Yu K

Mechanism-informed strategies therefore target sources and nodes rather than applying blanket antioxidants: source-targeted ROS amplification inside tumors (e.g., radiotherapy or certain chemotherapies combined with ferroptosis inducers and microenvironmental iron loading to accelerate lipid peroxidation) can overwhelm malignant buffers, while node inhibition (selective NOX isoforms, FSP1/CoQ rescue circuits, or lipid-peroxidation repair pathways) can re-sensitize resistant clones (Jiang et al

doi: 10.1165/rcmb.2002-0258OC 35 BerginDAReevesEPMeleadyPHenryMMcElvaneyOJCarrollTPet al

Yes, combining glutathione with other antioxidants and vitamins, like vitamin C, can enhance its efficacy

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Regarding the expression of DNMT1 and DNMT3a, our results showed that the expression of DNMT1 and DNMT3a in the ovary was significantly increased in the PCOS group, while quercetin treatment notably decreased their expression