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were the first to encounter CHAC1 expression in the context of cancer cell death ( CHAC1 gene is highly upregulated in HNSC cancer after treatment with nisin which was then followed by cell death ( CHAC1 gene even though basal CHAC1 expression is significantly lower than in normal tissues ( CHAC1 upregulation after exposing HT-1080 (fibrosarcoma cell line) and Calu-1 (non-small-cell lung cancer) cells to artesunate, whereas in more recent studies, a significant increase in CHAC1 expression in Burkitts lymphoma cells was observed ( CHAC1 is upregulated by the ATF4-CHOP cascade and leads to cell death by perturbation of the redox homeostasis through changes in the ROS levels ( The pathological significance of CHAC1 and ferroptosis extends beyond cancer, having also been established in various neurological disorders

T., & Kim, T.-Y

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In the field of genomics, by analyzing key information such as individual-specific target variations, mutation loads, complex mutation characteristics, and tumor-specific antigens, a solid theoretical foundation has been laid for the three pillars of precision medicinetargeted therapy, immune checkpoint inhibitors, and personalized anticancer vaccines (Miao and Van Allen, 2016

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