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These mechanisms act under both redox-sensitive and -insensitive conditions, influencing NRF2 at the transcriptional, post-transcriptional, and post-translational levels, and involving a range of proteins and epigenetic factors such as DNA methylation, histone modifications, and microRNA (Bryan et al

Magesh S, Cai D

(2022) 18:e1010963

The transmembrane (TM) domain and C-terminus of SARS-CoV-2 ORF3a are necessary for blocking autophagy We then sought to determine the underlying mechanism by which ORF3a blocks autophagosomelysosome fusion

425,426 In the heart tissue of conditional frataxin knockout mice, increased mRNA levels of MFRN2, SEC15L1, and TFR1 and decreased mRNA levels of FPN1 indicate an activated response to cytoplasmic iron deficiency and increased mitochondrial iron input

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