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Current strategies may work slowly, over months or years

21 ChenW.SeefeldtT.YoungA.ZhangX.GuanX

Cell Metabolism 23(6):1127-1139. [doi.org]

Genetics of mitochondrial electron transport chain in regulating oxygen sensing

For gut health and barrier function research, once-daily use is often enough, though twice-daily dosing may provide more consistent effects for acute conditions