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Compared to UBE2m RK, fatty acid metabolism and mitochondrial respiration were inhibited after re-expression of UBE2m WT, and the suppressed OCR was rescued significantly after treatment with MLN4924 (Figs

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In addition, AS-IV inhibited intestinal FXR signaling, reduced intestinal FGF15 expression, thereby reducing liver FXR activation, increased glucagon-like peptide-1 secretion, and ultimately suppressed SREBP-1c-mediated lipogenesis and liver steatosis (Zhai et al., 2022)

Sikiric et al., 2018), as well as its therapeutic effect in the gastrointestinal tract (Sikiric et al., 2010

The cytosolic and nuclear proteins were isolated as described in the nucleoprotein extraction kit (Beyotime Biotechnology, Nanjing, Jiangsu, China)