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Major limitations include difficulties in maintaining the complex three-dimensional architecture of seminiferous tubules, establishing appropriate hormonal microenvironments, and sustaining long-term culture conditions necessary for the extended timeline of human spermatogenesis

A vitamin B deficiency has been linked to mental health problems including depression

Most common are gastrointestinal side effects, including diarrhoea, vomiting, nausea and abdominal pain

Teitelbaum, D., Meshorer, A., Hirshfeld, T., Arnon, R

For animals with chronic conditions or ongoing nutritional requirements, it may be given periodically, such as once every two to four weeks