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J Foot Ankle Surg 46:411414 Sharma AR, Jagga S, Lee SS, Nam JS (2013) Interplay between cartilage and subchondral bone contributing to pathogenesis of osteoarthritis

They then identified its binding partner as prohibitin, establishing PHB as a vascular marker of white fat

Both compounds have demonstrated favorable safety profiles in preclinical and early clinical research, but combination use has not undergone Phase III human trials