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This risk can increase with improper nutrient intake

Cholinergic REM induction test: muscarinic supersensitivity underlies polysomnographic findings in both depression and schizophrenia

Reitman recommends baseline blood work to confirm deficiency and rule out other causes of fatigue

[DOI] [PubMed] [Google Scholar] 14.Indicators for assessing folate and vitamin B-12 status and for monitoring the efficacy of intervention strategies

However, some eventually discontinue use due to concerns over long-term side effects or lack of clear regulatory oversight