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This sequence of events is recapitulated in a humanized mouse model of diabetes, in which the presence of autoreactive T-cells alone was insufficient to induce disease, which was triggered only when -cells were stressed by the addition of the diabetogenic agent, streptozotocin (STZ) (32)

Orphan nuclear receptor ERR controls macrophage metabolic signaling and A20 expression to negatively regulate TLR-induced inflammation

Central Nervous System effects may be transient and disappear altogether on continued usage with dose reduction, but occasionally they are of such severe nature that therapy must be discontinued altogether

2022;17(4):e202100642

Pathologic anti-I antibody has a broad thermal range (0C to 32C) whereas normal anti-I in healthy individuals has a thermal range of 0C to 22C