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The mechanisms by which copper contributes to disease pathogenesis form an intricate network, centrally involving copper dyshomeostasis and its consequences, including oxidative stress (Rodriguez et al., 2024), protein aggregation (Zou et al., 2021), immune escape (Yi et al., 2022), angiogenesis (Tao et al., 2021)

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Tumor hypoxia: Classification, detection, and its critical role in cancer progression

It was originally FDA-approved for diagnosing and treating growth hormone deficiency in children, and its decades of clinical use have established a well-documented safety profile

Endocrinology 160 (6), 13631376

I., Huber, W., & Anders, S