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Conversely, in cellular contexts dependent upon Parkin-mediated mitophagy for survival, interference with this pathway via MST1-p53 axis activation or FFAR2/PPAR- signaling blockade enhances cellular susceptibility to ferroptosis upon Erastin treatment

followed eight patients with congenital lactic acidosis who received oral DCA (5.12 mg/kg every 9 h) for a duration ranging from 5.1 to 7.16 years, during which their renal, liver, electrolyte, and hepatic statuses remained stable [128]