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This activation reduces HO levels, increases CAT activity, and upregulates transcription of antioxidant genes, including HO-1, which help maintain redox homeostasis 17

In contrast, the cave populations have undergone evolutionary changes, resulting in reduced pigmentation, and degenerated or non-functional eyes, as they inhabit dark cave environments with limited or no access to light (Krishnan and Rohner 2017

In light of the protective effects of SARM1 knockdown in MASLD, these compounds may offer therapeutic

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