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322 Although it is not clear how the deacetylase acts as a coactivator to promote anti-oxidation genes in MSC, this study shows that SIRT6 is crucial to mediate the anti-stress and anti-ageing effect of MSC

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Dobbin JP, Harth M, McCain GA, Martin RA, Cousin K

In primary astrocyte cell cultures derived from the SOD1 mutant mouse model of ALS, defects in oxidative phosphorylation have been identified (123)

Singular and short-term anesthesia exposure in the developing brain induces persistent neuronal changes consistent with chronic neurodegenerative disease