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Starting on the eighth day, we administered AZM orally at a daily dose of 30 mg/kg for 14 days

Ratios of classical monocytes (CD14-/CD16-), which are more responsible for phagocytosis and initiation/priming of the immune system [254], are higher in patients with ALS and pre-symptomatic SOD1 carriers as compared with healthy controls, but function at a decreased efficacy and invade the CNS, though the difference between the roles of monocytes in the CNS versus systemic circulation are still unknown [255]

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In addition, WT mice showed an evident difference in day/night LTP, which was absent in melatonin and melatonin receptor-deficient mice, highlighting the circadian regulatory effect of melatonin on LTP [216]