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Throughout these stages, macrophages are closely associated with the ductal epithelium and thought to function in maintaining tissue homeostasis by clearing apoptotic debris and by providing key paracrine signals to the adjacent epithelium (13, 14, 15, 16, 17)

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The randomized and placebo-controlled design of all included trials and the double-blind design of most of them can also be other strengths and due to the RCT nature of the studies, the drugs used by the patients (especially in diabetic patients), the diet and the level of physical activity of the participants were controlled and in fact their effects were considered and it can be said that the pure effects of L-carnitine was evaluated

45 JaruskovaM.CurikN.HercogR.PolivkovaV.MotlovaE.BenesV.et al (2017)

Serum concentrations of beta-carotene, vitamins C and E, zinc and selenium are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population