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Metformin: a prospective alternative for the treatment of chronic pain

Avoid changing multiple variables at once

Further research is needed to elucidate these mechanisms better and, through evidence-based therapeutic strategies, enable the use of Cannabis sativa

10.1002/jcc.20290 32 CavasottoC

The compounds demonstrated different pharmacology in vivo, with TLC-2716 having lower plasma exposures and higher and sustained ileum and liver exposures (due to active uptake into hepatocytes) than TLC-6665 (ratio of AUCs of TLC-2716/TLC-6665 in plasma and liver of 0.17 and 6.24, respectively