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Histological analysis revealed that anagen hair follicles in anti-VEGFtreated mice were thinner (Figure 5, c and d) with a more than 30% reduction in bulb diameters (Figure 5e), mainly due to reduced thickness of the follicular epithelium, associated with a significant, more than 40% decrease of perifollicular vascularization (Figure 5, f and g)

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Stefanelli, V

These cognitive involvements are thought to be related and closely linked to psychiatric manifestations of the disease

This is supported by evidence that antibodies to TNF exist to some extent even in healthy subjects (3234) and in individuals with autoimmune disease (35), while a similar literature does not exist for antibodies to TL1A