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SARS-CoV-2 ORF6 protein has also been shown to dysregulate redox homeostasis by decreasing Nrf2 expression, which can enhance viral replication 69

Genetic alterations can also result in signaling protein deregulation, either upstream or downstream of the therapeutic target, resulting in acquired resistance

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In addition, the benefits of glutathione for skin extend to supporting immunity and maintaining overall cellular health

found that special IKK genetic deletion in the astrocyte attenuated phenotypes of obesity, such as weight gain, glucose intolerance, and insulin resistance, in obesity mice [100]

As compared to dyes, ligand-protected AuNCs present much greater two-photon absorption cross sections 13,28,29 , making them promising candidates for multiphoton excited fluorescence microscopy 30,31,32