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'Astragaloside IV (AS-IV)', 'fibrosis', 'pharmacokinetics', 'toxicity', 'bioavailability', and other keywords were used for retrieval, with relevant case reports, conference abstracts and duplicate studies being excluded

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Based on all these data, a novel pathogenetic model has been proposed which postulated that changes in the local metabolic environment (pH, salt) may play a key role in the development of AS by induction of a pro-inflammatory phenotype

The conventional approach of diagnosing one or the other and treating accordingly produces partial results at best because half the picture is being addressed and half is being ignored or actively worsened